• Proven to enhance delivery of compounds
  • Delivers active ingredients to the blood stream within seconds
  • Multiple absorption points
  • Superior absorption over capsules, tablets and powders
  • Safe & non toxic delivery system

Absorption & Delivery

The key problems faced with almost every dietary ingredient or drug is absorption. They will all degrade to some degree during digestion, they wont dissolve completely and ingredients that are not completely dissolved wont absorb into the body and will struggle to deliver enough active ingredient to cause the desired results, this is exactly where a SEDDS can be used.

What is SEDDS?

Regular tablets, pills or powers are often not dissolved or dispersed completely or efficiently. This leads to a high amount of active ingredients not being absorbed through the digestive walls before excretion. SEEDS is an oral delivery technology with specific pharmacutical excipients designed to enhance the absorption of active ingredients from 3 points, the mouth, esphagus and the gastrointesinal tract. When dosing, SEEDS can be held in the mouth for sub-lingual absorbtion through the veins and gums in your mouth before swollowing or simply swallowed. (Sub-Lingual will result in better results with an even faster delivery rate)

The simplest way to understand SEDDS would be an entrapment of the active ingredients within the SEDDS. The stomach cannot break down the actives as they are protected in the SEDDS and you can achieve a delivery of your actives intact and ready for absorption.

Once in the digestive tract the SEDDS sticks to the digestive walls like sticky honey. SEDDS starts forcing the active ingredients into the walls at higher concentrations than normal when compared to powdered tablet form. This allows for massive increases in the percentage of delivery.

SEDDS has the ability to stick and penetrate the digestive walls at higher percentages compared to regular tablets or pills, due to select pharmaceutical excipients. This process is vital to absorbing as much as possible of the active ingredients.

Regular tablets, pills or powders are often not dissolved or dispersed completely or efficiently. This leads to a high amount of the actives not being absorbed through the digestive walls before excretion.

SEDDS Technology is well established and utilized by the pharmaceutical industry. (1-15) SEDDS have been proven to enhance the absorption of active ingredients from as much as 200% increase for poorly soluble ingredients to 1500% for highly soluble ingredients by dispersing the active ingredients into a highly bio-available emulsion. (7-10) To understand exactly how an emulsion increases the uptake of active ingredients it’s important to understand how an emulsion is formed.

First of all, an emulsion is simply an even dispersion of two immiscible liquids, such as oil and water. In order to create an emulsion, SEDDS utilizes a blend of unique fatty esters, represented in the image below –

Because standard fat molecules have a high proportion of fat solubility they naturally stick together and form larger fat droplets, even after digestion through the stomach. (20, 21)

However, in comparison to standard fat molecules, the fatty esters have a higher proportion of water soluble surface area and therefore increased water solubility. Immediately after being mixed with water or stomach fluid, the fatty esters are able to disperse into small micro-droplets and form completely stable emulsions. (8, 9, 25)

The micro-droplets formed by the fatty esters are known as micelles. Micelles are microscopic spherical structures (50-150nm) that form when fatty esters are mixed into an aqueous liquid. Active ingredients are forced to partition into these fat soluble micelles. (3, 8, 9, 25)

Immediately after mixing SEDDS in stomach fluid it creates an emulsion which disperses the active ingredients into micellar structures.


How does SEDDS enhance the absorption of active Ingredients?

SEDDS enhances absorption of active ingredients by 3 primary mechanisms

1. Molecular dispersion of a compound is a requirement for absorption across a biological membrane surface. SEDDS delivers active ingredients in a molecular dispersed form, allowing them to easily penetrate and stick to the cellular membranes lining the mouth, esophagus and intestinal surface. (1, 19, 26)

2. The water soluble micelles formed by SEDDS are able to carry active ingredients past the aqueous barrier to reach the surface of the cellular membranes. (1, 6, 18)

3. Penetration of the cellular membranes is enhanced by SEDDS fatty esters and pharmaceutical excipients which penetrate the lipid bilayer of the cells surface. This enhances penetration of the active ingredients into the cells. (6, 8, 9, 15)

Below is a representation of how SEDDS enhances delivery of active ingredients through the intestinal track –

Ingredients that are not completely dissolved or dispersed won’t absorb into the body. Here you can see regular pills, tablets or powder that fail to disperse and cannot be absorbed completely and efficiently.

How fast does SEDDS start delivering active ingredients to my blood stream? Is it timed released?

Immediately after consuming SEDDS the active ingredients are penetrated through the biological membrane surfaces of the mouth and esophagus before reaching the digestive tract for the 3rd absorption point. Within seconds, the active ingredients are absorbed and carried to the blood stream. (1, 19, 26)

SEDDS can sustain heightened blood levels of active ingredients for up to 10-12 hours. Beyond this point, the half-life of the active ingredient(s) in the blood stream will depend on the level of metabolism and excretion.

Does SEDDS have any side-effects?

The ingredients in SEDDS are food grade and safe for human consumption. (9, 23) Because SEDDS was designed as a low surfactant based formula with a stable pH level it is easily digested and well tolerated by almost all individuals, even those with sensitive digestive systems.

In some individuals, drinking SEDDS may cause a slight burning sensation in the throat. To prevent this, SEDDS can be taken with or followed by water (or drink of your choice) to make the taste more acceptable.

When should I take SEDDS? Can I take it with food or other supplements?

For dosing time, it is best to follow the unique recommendation for the given product.

We recommend for best results to try to take SEDDS on an empty stomach.

WARNING: SEDDS may enhance the delivery of other supplements and/or medications. Therefore, it is important to consult your practitioner prior to consuming prescription medication or supplements in conjunction with SEDDS.

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