Endocrine Amplifier

  • Powerful Endocrine Amplifier
  • Important Phospholipid complex
  • Minimize Cortisol response to exercise and stress
  • Increase GH response
  • Improved Recovery rates
  • Improved Memory and Brain Function

Overcoming the sticking point on that final bicep curl. Defying exhaustion to power through that unattainable extra set.

Lifting more than your mates.

Occasionally this happens, but not as often as we’d like. Training gains tend to plateau, and we might fail to see gains for weeks or months on end…….Until now!

Introducing Endocrine Amplifier, our clinically proven natural phospholipid complex.

Endocrine Amplifier improves your hormonal response to resistance exercise and muscle synthesis, which in turn maximises recovery and muscle gain.

What’s more, the ingredients of Endocrine Amplifier have been shown to sharpen mental focus and decrease the endocrine response to stress, so you’re able to push your limits and pump out that extra set where others can’t.

Supplement Facts

Serving Size: 3 Capsules
Servings per container: 30 (90 capsules)

Amount Per Serving %DV

50% Phosphatidylserine 1600mg*

Phosphatidylserine 800mg*
Phosphatidylcholine 154mg*
Phosphatidylethanolamine 128mg*
Phosphatidylinositol 68mg*

50% A-GPC (alpha-glyceryl phosphoryl choline) 600mg*
(sn-Glycero-3-phosphorylcholine)

Other Ingredients:
Vcaps® Capsules
Hypromellose (vegetarian capsules)
*Contains Soy
*Daily Value not established
Optimize Muscle Building and Repair

Endocrine Amplifier optimizes your hormone levels and balance to enhance post-exercise muscle fiber repair. This way you’re guaranteed to get the absolute maximum return from the hard work, time, and money you put into each of your sessions.

  • Minimizes the damaging effects of cortisol, ensuring you gain size as fast as possible.
  • Protects and boosts testosterone production which reduces muscle soreness so you can get back to the gym quicker.
  • Improve the testosterone to cortisol ratio, enhancing the muscle building process.
  • Enhance resistance to stress & fatigue which helps you smash through sticking points.shutterstock_83491552

 

Reducing Cortisol

It is well established that lower levels of testosterone can hinder muscle synthesis and subsequent strength gains, so maintaining high testosterone levels is always desirable when weight training.

Unfortunately, one of our main exercise-induced hormones cortisol, reduces the body’s creation of testosterone (1-9). Having what’s known as a low testosterone to cortisol ratio is associated with decreased performance, slower recovery rates and difficulty gaining muscle mass (10,11).

The main role of cortisol is to break down body tissue including muscle tissue in order to harness nutrients for other body processes (12). Something not many people want when trying to build muscle.

After strenuous exercise when muscle tissue needs repair (from nutrients such as amino acids and phospholipids), cortisol can be triggered into action once more, breaking down muscle tissue from other parts of the body if there is not enough high quality nutrients available.

Phosphatidylserine (PS)

We now know there is a proven way to reduce the level of cortisol produced by the body. It’s been researched in more than 40 human clinical trials over a period of more than 30 years.

Enter Phosphatidylserine (PS) – one of the main ingredients of Endocrine Amplifier.

PS is a vital phospholipid that supports testicular function and testosterone production (13,14) by dampening our body’s cortisol response. PS is thought to do this by boosting phospholipid supply required for cellular membrane structure and function. This reduces the body’s breakdown of proteins and nutrients (15-18).

It also supports testosterone production by increasing the male testes sensitivity to Luteinizing Hormone (LH). LH signals testosterone production from the male testes (1-2,6,8).

By reducing the damaging effects of cortisol, enhancing phospholipid supplies, and increasing sensitivity to LH, the clinical dose of PS in Endocrine Amplifier produces a superior environment for testosterone production.

A recent study examining the effects of 10 days of 600mg/day PS supplementation on testosterone and cortisol during and after exercise found that those supplemented had increased testosterone by 78% over the placebo controlled group. (14) Their cortisol response to exercise was heavily blunted by 39%.cortisol_levels_test_on_ps

In a second human study, hormone levels were monitored for two weeks of intense weight training. The group receiving the 800mg of PS had higher testosterone levels and lower cortisol levels, compared to the control group receiving the placebo (13).

A third study involving elite level cyclists showed that 800mg of PS reduced post workout cortisol levels by 39% (compared to the placebo group) (19).

Enhanced Endurance

PS has also been shown to increase endurance levels and exercise capacity (20, 21). By reducing cortisol levels, resistance to stress and fatigue is enhanced. The longer it takes for muscle fibers to reach fatigue, the longer you can train.

Enhanced Recovery and Gains

Endocrine Amplifier is clinically formulated to promote faster workout recovery, as well as significantly enhance fat loss. Less time spent nursing sore muscles, and more time spent driving the bench press bar, equals more strength and more size.

  • Increase growth hormone (GH) sensitivity to help cells rebuild and reshape muscle fibres faster.
  • Increase GH levels during exercise which significantly increases your peak muscle strength and performance.shutterstock_178345331

Increase GH response

Growth Hormone (GH) is a hormone that stimulates muscle growth through cellular regeneration and reproduction. Highly advantageous for those looking to gain size fast, but in a natural way. GH production may be triggered after exercise by a neurotransmitter known as acetylcholine (21-26).

One of the main ingredients in Endocrine Amplifier has been clinically proven to enhance the production and release of acetylcholine and subsequent GH levels in humans.

A-GPC

Alpha-glycerylphosphorylcholine (A-GPC) is a natural choline compound found in the brain. Via a stimulating hormone, it is thought to enhance the production of acetylcholine, which in turn enhances the sensitivity and release of growth hormone (GH) in your system (22). Higher GH is associated with increased exercise performance.

In 2008, a placebo controlled trial study investigated GH responses in weight trained males after supplementation with a single 600mg dose of A-GPC. The A-GPC supplemented group had GH levels peak 68% higher than the placebo group, post workout. Additionally the peak bench press force was 14% higher than the placebo (21).

Another human study investigated effects of A-GPC on the young and elderly. In the young subjects (30-34 yrs), A-GPC contributed to a 40% higher increase in GH over the placebo group. In the elderly subjects (80-82 yrs), A-GPC caused a massive increase of GH by 140% over the placebo group (22).

Sharpen Focus and Memory

The two main ingredients of Endocrine Amplifier, Phosphatidylserine (PS) and Alpha-glycerylphosphorylcholine (A-GPC), are clinically proven to enhance overall brain function by alleviating memory loss, cognitive impairment, and dementias of various kinds.

  • Enhances release of acetylcholine, sharpening agility and delaying mental fatigue.
  • Increases brain metabolism to sharpen your focus and concentration.
  • Stalls or even reverses age-related brain function decline, which leads to improved learning ability and memory recall.
  • Alleviates stress, including mental stress which enhances your daily mood.shutterstock_94968319

The Medical Practitioners Go-To Supplement

For many health professionals treating age-related cognitive decline, such as dementia and Alzheimer’s disease, A-GPC is part of the first line of treatment. It’s known to significantly enhance the production and release of acetylcholine, the neurotransmitter heavily involved in all key brain functions and mental cognition.

In fact, research on A-GPC has been so resounding that it is widely used in clinical settings around the world as the go-to dietary supplement.

A therapeutic dose of A-GPC given in a clinical trial of over 2000 recent stroke sufferers found that cognitive recovery was significantly improved in patients receiving A-GPC, when compared with placebo (27).

Improves Dementia and Cognitive Dysfunction

Mental health and brain function benefits are also observed with supplementation of phosphatidylserine (PS). This is due to the ability of PS to increase communication between brain cells by increasing the number of receptors as well as modulating the fluidity of cell membranes.

A reversal in brain aging of nearly 14 years was found after 12 weeks of supplementation with 300 mg per day of PS. Improvements were seen for learning and remembering of written information, remembering names, recognizing faces, and recalling numbers (28).

graph_years_of_improvement

Increases Metabolism Throughout Your Brain

PS supplementation has been shown to increase glucose metabolism in the brain (glucose is the sole nutrient the brain utilises for fuel) (29). Below is PET imaging of the brain of a 59-year-old woman which shows metabolism is increased in almost all brain regions after PS supplementation. The colour scale indicates regional glucose metabolism at three brain levels- red is most intense and blue is least.

illus_brainScan

UPPER: before PS; LOWER: after taking 500 MG PS daily for three weeks.

Benefits Mood and Attention-deficit hyperactivity disorder (ADHD)

First pilot studies indicate that PS supplementation may be beneficial for children with attention-deficit hyperactivity disorder (30-31).

A follow-up study backed up previous findings. The study found children supplementing with 200 mg PS per day for two months saw a significant improvement in ADHD symptoms (32). This is believed to be due to increased levels of dopamine (the feel good hormone) that is stimulated by PS supplementation (33-35).

graph_dopamine

Additional placebo controlled and double-blinded studies also found the enhanced mood effects of PS supplementation to reduce mental stress (36) and increase stress resistance. These effects have even been shown to improve golfers’ accuracy at tee-off (37).

Dosage and How To Use

Alpha-glycerylphosphorylcholine (A-GPC) and Phosphatidylserine (PS) are naturally present in animal products, however for most people the Western diet does not provide PS in amounts sufficient to provide the clinically proven benefits of Endocrine Amplifier (15,38,39).

Each serving of Endocrine Amplifier provides a scientifically proven dose of A-GPC and PS.

Recommended Use: As a dietary supplement take 3 capsules once daily with or without food. Store in a dry cool place away from light.

Not for pregnant or breastfeeding women. Not to be used as a sole source of nutrition, This product is not intended to diagnose, treat, cure, or prevent any disease.

Can I stack Endocrine Amplifier with other testosterone support supplements?

Yes, Endocrine Amplifier can enhance the effectiveness of other testosterone boosting supplements by increasing the testes ability to create and enhance testosterone production.

This synergistic effect can make Endocrine Amplifier an important addition in conjunction to The Ultimate Stack. It also makes Endocrine Amplifier a vital part of post cycle therapy (PCT), when preserving muscle mass and restoring natural testosterone production.

The Ultimate Stack986x552-LR-Trans-Toco

 

All 3 products can be stacked together to have a synergistic effect to further enhance testosterone levels.

1. Testosterone levels during systemic and inhaled corticosteroid therapy. D Morrison, et al. Respir Med, October 1, 1994; 88(9): 659-63.

2. Testicular function during prolonged corticotherapy JM Kuhn, et al. Presse Med, March 22, 1986; 15(12): 559-62.

3. Glucocorticoid Induces Apoptosis in Rat Leydig Cells Hui-Bao Gao, et al. Endocrinology, Jan 2002; 143: 130.

4. Role of glucocorticoid in the stress-induced suppression of testicular steroidogenesis in adult male rats. Orr TE, Mann DR 1992 Horm Behav 26:350 – 363

5. Suppression of endogenous corticosterone levels in vivo increases the steroidogenic capacity of purified rat Leydig cells in vitro. Gao HB, Shan LX, Monder C, Hardy MP 1996 Endocrinology 137:1714 – 1718

6. Mutually independent effects of adrenocorticotropin on luteinizing hormone and testosterone secretion DR Mann, et al. Endocrinology, Apr 1987; 120: 1542.

7. Reciprocal changes in plasma corticosterone and testosterone in stressed male rats maintained in a visible burrow system: evidence for a mediating role of testicular 11ß-hydroxysteroid dehydrogenase. Monder C, et al. Endocrinology 134:1193 – 1198

8. The effect of stress-induced ligands on testosterone formation in Leydig cells. Cooke BA, et al. 1992 West AP, eds. Stress and reproduction. New York: Raven Press; 135 – 144

9. Acute suppression of circulating testosterone levels by cortisol in men. Cumming D, Quigley ME, Yen SSC 1983 J Clin Endocrinol Metab 57:671 – 673

10. Overtraining and elite athletes: Review and directions for the future. Kuipers et al. Sports Med. 1988, 6:79-92

11. Resistance exercise overtraining and overreaching neuroendocrine responses. Kraemer et al. Spots Med. 1997, 23(2):106-129

12. Association of 24-Hour Cortisol Production Rates, Cortisol-Binding Globulin, and Plasma-Free Cortisol Levels with Body Composition, Leptin Levels, and Aging in Adult Men and Women Jonathan Q. et al. J. Clin. Endocrinol. Metab., Jan 2004; 89: 281 – 287.

13. HORMONAL EFFECTS OF PHOSPHATIDYLSERINE DURING 2-WKS OF INTENSE WEIGHT TRAINING [Annual Meeting Abstracts] Fahey, T. D.; Pearl, M. California State University, Chico

14. The effects of soy phosphatidylserine on cortisol, growth hormone and testosterone response to moderate intensity exercise. Starks, et al. University of Mississippi

15. Brain caphalin, a mixture of phosphatides. Separation from it of phosphatidyl serine, phosphatidyl ethanolamine, and a fraction containing an inositol phophatide. Folch J et al. J Biol Chem 1942 146(1):35-44

16. Phospholipids and sports performance. R Jager, et al. J Int Soc Sports Nutr, Jan 2007; 4: 5

17. Amino acids and proteins for the athlete. Di Pasquale CRC Press, 2007, Pg 309

18. Phospholipids as dynamic participants in biological processes. Hanahan et al. J lipid Res 1984, 25:1528-1535

19. Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men. Monteleone et al. Eur J Clin Pharmacol 1992, 42(4):385-388

20. Effects of phosphatidylserine on exercise capacity during cycling in active males. Kingsley et al. Med Sci Sports Exerc 2006, 38(I):64-71

21. Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to and peak force production during resistance exercise Ziegenfuss et al. J Int Soc Sports Nutr, Jun 2008 5(Suppl 1): P15

22. Alpha-Glycerylphosphorylcholine administration increases the GH response to GHRH of young and elderly subjects. Ceda et al. Horm Metab Res, Mar 1992; 24(3): 119-21.

23. Phospholipids as dynamic participants in biological processes. Hanahan et al. J lipid Res 1984, 25:1528-1535

24. Biosynthesis of phospholipids Kennedy at al. Fed, Proc 16: 847-853 (1957)

25. A multicentre trial to evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. R Di Perri, G Coppola, LA Ambrosio, A Grasso, FM Puca, and M Rizzo J Int Med Res, July 1, 1991; 19(4): 330-41.

26. Behavioral effects of L-alpha-glycerylphosphorylcholine: influence on cognitive mechanisms in the rat. F Drago, F Mauceri, L Nardo, C Valerio, N Lauria, L Rampello, and G Guidi Pharmacol Biochem Behav, February 1, 1992; 41(2): 445-8.

27. Alpha-Glycerophosphocholine in the mental recovery of cerebral ischemic attacks. Barbagallo Sangiorgi G, et al. An Italian multicenter clinical trial. Ann NY Acad Sci 1994; 717:253-69

28. An open trial of plant-source derived phosphatidylserine for treatment of age-related cognitive decline. Schreiber S, Kampf-Sherf O, Gorfine M, Kelly D, Oppenheim Y, Lerer B. Isr J Psychiatry Relat Sci. 2000;37(4):302-7.

29. Effect of phosphatidylserine on cerebral glucose metabolism in Alzheimer’s disease. Klinkhammer P, Szelies B, Heiss WD. Dementia. 1990;1(4):197-201.

30. Effect of phosphatidylserine administration on symptoms of attention-deficit/hyperactivity disorder in children. Hirayama S, Masuda Y, Rabeler R (September/October 2006). Agro Food 17 (5): 32–36.

31. Correlation between changes in blood fatty acid composition and visual sustained attention performance in children with inattention: effect of dietary n-3 fatty acids containing phospholipids. Vaisman N, Kaysar N, Zaruk-Adasha Y, Pelled D, Brichon G, Zwingelstein G, Bodennec J (2008). The American Journal of Clinical Nutrition 87 (5): 1170–1180. PMID 18469236

32. The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial. Hirayama S., Terasawa K., Rabeler R., Hirayama T., Inoue T., Tatsumi Y., Purpura M. & Jäger R. (2013). Human Nutrition and Dietetics.

33. F. Casamenti, C. Scali, G. Pepeu. Phosphatidylserine reverses the age-dependent decrease in cortical acetylcholine release: a microdialysis study, Eur. J. Pharmacol 1991, 194, 11-16.

34. F. Pedata, L.Giovannelli, G. Spignoli, M.G. Giovannini, G. Pepeu. Phosphatidylserine increases acetylcholine release from cortical slices in aged rats.Neurobiol Aging 1985, 6, 337-339.

35. Phosphatidylserine effects on dopamine release from striatum synaptosomes. S.Mazzari, A. Battistella. In: Multidisciplinary Approach to Brain Development. C. Benedetta, R. Balazs, G. Gombos, G. Porcellani (Eds.). Elsevier/North Holland, Amsterdam, 1980, 569-570.

36. The Influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. Benton D, Donohoe RT, Sillance B, Nabb S (2001). Nutr Neurosci 4 (3): 169–178.

37. The effect of phosphatidylserine on golf performance. Jäger R, Purpura M, Geiss K-R, Weiß M, Baumeister J, Amatulli F, Schröder L, Herwegen H (December 2007). International Society of Sports Nutrition.

38. Food composition and nutritional tables. Souci et al. Medpharm Scientific Publishers; 2000

39. L–Glycerophosphocholine Contributes to Meat’s Enhancement of Nonheme Iron Absorption Charlotte N. Armah, Paul Sharp, Fred A. Mellon, Sandra Pariagh, Elizabeth K. Lund, Jack R. Dainty, Birgit Teucher, and Susan J. Fairweather-Tait J. Nutr., May 2008; 138: 873 – 877.

40. Phospholipids as dynamic participants in biological processes. Hanahan et al. J lipid Res 1984,  25:1528-1535

41. Biosynthesis of phospholipids Kennedy at al. Fed, Proc 16: 847-853 (1957)

42. A multicentre trial to evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. R Di Perri, G Coppola, LA Ambrosio, A Grasso, FM Puca, and M Rizzo J Int Med Res, July 1, 1991; 19(4): 330-41.

43. Behavioral effects of L-alpha-glycerylphosphorylcholine: influence on cognitive mechanisms in the rat. F Drago, F Mauceri, L Nardo, C Valerio, N Lauria, L Rampello, and G Guidi Pharmacol Biochem Behav, February 1, 1992; 41(2): 445-8.

44. L-Glycerophosphocholine Contributes to Meat’s Enhancement of Nonheme Iron Absorption Charlotte N. Armah, Paul Sharp, Fred A. Mellon, Sandra Pariagh, Elizabeth K. Lund, Jack R. Dainty, Birgit Teucher, and Susan J. Fairweather-Tait J. Nutr., May 2008; 138: 873 – 877.

45. Overtraining and elite athletes: Review and directions for the future. Kuipers et al. Sports Med. 1988, 6:79-92

46. Resistance exercise overtraining and overreaching neuroendocrine responses . Kraemer et al. Spots Med. 1997, 23(2):106-129

Frequently Asked Questions

If I am female or a child can I take Endocrine Amplifier?

Absolutely Endocrine Amplifier has many Endocrine benefits and has been widely studied for many different diseases in many age groups and in both male and females.

What if I have low cortisol? Will Endocrine Amplifier still work?

Although seemingly contradictory, the answer is yes. Strengthening the body with the vital phospholipids and nutrients in Endocrine Amplifier will assist the proper structure & function of the body.

Remember, insufficient cortisol production is usually caused by adrenal fatigue which generally originates from over production of cortisol. In order to restore the adrenal glands normal cortisol release, you must remove the hyper-cortisol stimulus, and reduce the demand for cortisol by providing the body with adequate nutrition.

Can I stack Endocrine Amplifier with other testosterone support supplements?

Yes, Endocrine Amplifier can enhance the effectiveness of other testosterone boosting supplements by increasing the testes ability to create and enhance testosterone production.

This synergistic effect can make Endocrine Amplifier an important addition in conjunction to The Ultimate Stack. It also makes Endocrine Amplifier a vital part of post cycle therapy (PCT), when preserving muscle mass and restoring natural testosterone production.

How many capsules are in 1 container?

There is 90 capsules enough to last 30 days at the recommended dosage.

What does it mean to reduce the demand for cortisol?

Cortisol is a catabolic hormone produced by the body to breakdown bodily tissue and free up nutrients for the repair and maintenance of the body. (12)The-endo-system

Cortisol Secretion

  1. When the brain senses low levels of vital nutrients (e.g., glucose, phospholipids, etc.), it releases adrenocorticotropic hormone (ACTH) which stimulates the adrenal glands.
  2. Once ACTH stimulates the adrenal glands it releases cortisol to begin breaking down body tissue. (12)

When muscle tissue is damaged from exercise it has an increased need for nutrients (e.g., amino acids and phospholipids) for the structural muscle tissue repair. Therefore, if the body is not supplied with enough nutrition to repair and rebuild the damaged muscle tissue, it will release cortisol to breakdown other areas of the body for the nutrients it requires.

Research has also shown that cortisol can break down testicular tissue andreduces the body’s creation of testosterone, possibly as a method to free up phospholipid stores within the testes to be used else where in the body. (2-10)

Studies with over-trained athletes or athletes who have not received sufficient nutrition have shown that elevated cortisol levels are connected with lower testosterone. This is commonly known as a low testosterone to cortisol ratio and is highly associated with a decreased in performance, slower recovery rates and difficulty in gaining muscle mass. (45,46)

Therefore, when the body is given enough nutrients to repair muscle damage, it reduces the need for cortisol.