Tauroursodeoxycholic Acid (TUDCA) 125mg*
Polyenylphosphatidylcholine (PPC) 450mg*
N-Acetyl Cysteine (NAC) 600mg *
S-Adenosyl-L-Methionine Disulfate Tosylate (SAMe) 200mg*
Soon after taking oral androgens it becomes apparent that excessive doses or prolonged use can be damaging to liver function, (14) and since there have been several case studies of jaundice and liver failure secondary to oral androgen use, both self-administered (15) and in a clinical setting. (16,17) The liver toxic effects of oral androgens are of a primarily cholestatic nature(liver damaging). This leads to impaired bile flow at low concentrations. These retained bile salts cause programmed cell death and at higher concentrations, necrosis and severe liver damage.
It was designed with users of oral androgens in mind, and brings together the best anti-cholestatic ingredients available. Each ingredient in Cycle Guard has been specifically chosen to help combat the effects of oral androgens on the liver.
- Can prevent programmed cell death and strongly stabilizes mitochondrial membranes (1)
- When used consistently, TUDCA eventually becomes the predominant bile acid in the liver and in general circulation. (2)
- Directly stimulates bile export and secretion which helps digestion, cleansing of toxins and hormone production (3,4,5)
- Stabilizes cellular membranes and dilates bile canaliculi (fine tubular channels forming a three-dimensional network within the parenchyma of the liver. They join to form the bile ductiles and eventually the hepatic duct.) This has been shown to protect human cells from accumulation of toxic bile salts within the hepatocyte (A hepatocyte is a cell of the main tissue of the liver. Heptocytes make up 70-85% of the liver’s cytoplasmic mass) An accumulation of toxic bile salts can cause serious liver damage (6,7)
- Oral androgen administration may decrease liver values all of which may be restored, and even raised, by the use of PPC (polyenylphosphatidylcholine) (8)
- PPC is secreted into bile by hepatocytes, where it serves as a major component of the micelles in which bile acids are emulsified. Increased levels of phosphatidylcholine reduces the toxicity of bile acids (9)
- Is both a metabolite of and a precursor to glutathione, a naturally-occurring peptide that is important in the detoxification of lipophilic toxins in the liver. (10)
- Functions as an anti-oxidant to minimise oxidative stress to cells caused by reactive oxygen species (11)
- Has anti-inflammatory properties and may reduce levels of inflammatory cytokines. (12)
- May minimise muscle fatigue during exercise (13)
- Is a precursor to glutathione, which may be able to prevent androgen induced cholestasis and liver injury.
- Can inhibit bile acid induced hepatocyte programmed cell death, (18,19,20) reduces the inflammatory cytokine TNF-alpha, (21,22) and can reduce oxidative stress via glutathione replenishment, (23) which may also play a role in treating the effects of cholestasis (liver damage). (24)
- Has been studied extensively as a safe and effective treatment for pregnancy induced cholestasis (liver damage) (25,26,27) and in a case study, was even shown to reverse severe androgen induced cholestasis. (28) Due to its distinct mechanism of action it has an additive effect when used alongside TUDCA. (18,26)
- As a direct precursor to glutathione the benefits associated with SAMe use are not limited to liver protection. It is also in wide use as a general antioxidant and anti-inflammatory.
Store in a dry cool place away from light.
All 3 products can be stacked together to have a synergistic effect to further enhance testosterone levels.
1. Joana D. Ameral, Ricardo J. S, Viana, Rita M. Ramalho, Clifford J. Steer, and Cecília M. P. Rodrigues (2009), “Thematic Review Series: Bile Acids: Bile acids: regulation of apoptosis by ursodeoxycholic acid”, J. Lipid Res, 50(9) 1721-1734. doi: 10.1194/jlr.R900011-JLR200
2. Trauner and Graziadei (1999), “Review article: mechanisms of action and therapeutic applications of ursodeoxycholic acid in chronic liver diseases”. Aliment. Pharmacol. Ther, 13: 979–995. doi: 10.1046/j.1365-2036.1999.00596.x
3. Dieter Häussinger, Anna Kordelia Kurz, Matthias Wettstein, Dirk Graf, Stephan Vom Dahl, Freimut Schliess (2003), “Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis “, Gastroenterology,124(5), 1476-1487
4. Ulrich Beuer (1997), “Effects of Bile Acids on Hepatocellular Signaling and Secretion”, YJBM, 70, 341-346
5. Frank Dombrowski, Bruno Stieger and Ulrich Beuers (2006), “Tauroursodeoxycholic acid inserts the bile salt export pump into canalicular membranes of cholestatic rat liver”, Laboratory Investigation, 86, 166–174. doi:10.1038/labinvest.3700371
6. Häussinger D, Kurz AK, Wettstein M, Graf D, Vom Dahl S, Schliess F (2003), “Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis”, Gastroenterology, 124(5), 1476-1487
7. Kolde G, Kessler E, Van Husen N, Themann H (1978), “Ultrastructural-morphometric analysis of polyenylphosphatidylcholine [PPC] treated cholestatic rat liver”, Z Gastroenterol, 16(10), 625-639
8. Françoise Chanussot and Liliane Benkoël (2003), “Prevention by dietary (n-6) polyunsaturated phosphatidylcholines of intrahepatic cholestasis induced by cyclosporine A in animals”, Life Science, 73(4), 381–392
9. Gonzales E, Davit-Spraul A, Baussan C, Buffet C, Maurice M, Jacquemin E (2009), “Liver diseases related to MDR3 (ABCB4) gene deficiency”, Front Biosci., 14, 4242-4256
10. Roes EM, Raijmakers MTM, Peters WHM, Steegers EAP. Effects of oral N-acetylcysteine on plasma homocysteine and whole blood glutathione levels in healthy, non-pregnant women. Clin. Chem. Lab. Med. 2002 May;40(5):496–8.
11. Dodd S, Dean O, Copolov DL, Malhi GS, Berk M. N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility. Expert Opin Biol Ther. 2008 Dec;8(12):1955–62.
12. Arranz L, Fernández C, Rodríguez A, Ribera JM, De la Fuente M. The glutathione precursor N-acetylcysteine improves immune function in postmenopausal women. Free Radic. Biol. Med. 2008 Nov 1;45(9):1252–62.
13. Kerksick C, Willoughby D. The Antioxidant Role of Glutathione and N-Acetyl-Cysteine Supplements and Exercise-Induced Oxidative Stress. Journal of the International Society of Sports Nutrition. 2005 Dec 9;2(2):38.
14. WERNZE H. Clinical research on the problem of liver damage by certain androgenic and anabolic steroids. Dtsch. Med. Wochenschr. 1960 Dec 16;85:2237–42.
15. Krishnan PV, Feng Z-Z, Gordon SC. Prolonged intrahepatic cholestasis and renal failure secondary to anabolic androgenic steroid-enriched dietary supplements. J. Clin. Gastroenterol. 2009 Aug;43(7):672–5.
16. Westaby D, Ogle SJ, Paradinas FJ, Randell JB, Murray-Lyon IM. Liver damage from long-term methyltestosterone. Lancet. 1977 Aug 6;2(8032):262–3.
17. GORDON BS, WOLF J, KRAUSE T, SHAI F. Peliosis hepatis and cholestasis following administration of norethandrolone. Am. J. Clin. Pathol. 1960 Feb;33:156–65.
18. Benz, Angermüller, Klöters-Plachky, Sauer, Stremmel, Stiehl. Effect of S-adenosylmethionine versus tauroursodeoxycholic acid on bile acid-induced apoptosis and cytolysis in rat hepatocytes. European Journal of Clinical Investigation. 1998;28(7):577–83.
19. Ansorena E, García-Trevijano ER, Martínez-Chantar ML, Huang Z-Z, Chen L, Mato JM, et al. S-adenosylmethionine and methylthioadenosine are antiapoptotic in cultured rat hepatocytes but proapoptotic in human hepatoma cells. Hepatology. 2002;35(2):274–80.
20. Yi-Sheng Liu, Wei Cai, Sheng-Mei Wu, Long-Hua Qian. Effect of S-adenosylmethionine on total parenteral nutrition-associated cholestasis. World J Pediatr 2007;3(3):218-221
21. Purohit V, Abdelmalek MF, Barve S, Benevenga NJ, Halsted CH, Kaplowitz N, et al. Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. Am. J. Clin. Nutr. 2007 Jul;86(1):14–24.
22. Chawla RK, Watson WH, Eastin CE, Lee EY, Schmidt J, McClain CJ. S-adenosylmethionine deficiency and TNF-alpha in lipopolysaccharide-induced hepatic injury. Am. J. Physiol. 1998 Jul;275(1 Pt 1):G125–129.
23. Michael Brown J, Ball JG, Wright MS, Van Meter S, Valentovic MA. Novel protective mechanisms for S-adenosyl-L-methionine against acetaminophen hepatotoxicity: improvement of key antioxidant enzymatic function. Toxicol. Lett. 2012 Aug 3;212(3):320–8.
24. Copple BL, Jaeschke H, Klaassen CD. Oxidative stress and the pathogenesis of cholestasis. Semin. Liver Dis. 2010 May;30(2):195–204.
25. Frezza M, Centini G, Cammareri G, Le Grazie C, Di Padova C. S-adenosylmethionine for the treatment of intrahepatic cholestasis of pregnancy. Results of a controlled clinical trial. Hepatogastroenterology. 1990 Dec;37 Suppl 2:122–5. 26. Nicastri PL, Diaferia A, Tartagni M, Loizzi P, Fanelli M. A randomised placebo-controlled trial of ursodeoxycholic acid and S-adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy. Br J Obstet Gynaecol. 1998 Nov;105(11):1205–7.
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28. Bray GP, Tredger JM, Williams R. Resolution of danazol-induced cholestasis with S-adenosylmethionine. Postgrad Med J. 1993 Mar;69(809):237–9.
1. brother i was pissing what looked like coca cola colour at one stage… i jumped onto 3 cycle guard a day and it almost instantly cleared up to a yellowish… i was STILL on high doses… upped my water to 4L a day and took 6 and it comes out clear now. http://www.bodybuildingforums.com.au/pct-post-cycle-therapy-oct-on-cycle-therapy/4566-liver-support.html#post82100
2. 100% cycle guard. Tudca is the best… i was pissing tren colour when i was on milk thistle and orals… now im back to normal. 3 a day. laughing!http://www.bodybuildingforums.com.au/supplement-reviews/4390-milk-thistle-vs-liver-supplements.html#post80908
3. I’m using Cycle Guard now for 4 weeks, going to start my second bottle soon. Gotta say no matter how high I run orals so far no change in my piss colour http://ausbb.com/showthread.php?t=22650&p=594736&viewfull=1#post594736
Frequently Asked Questions
How many capsules are in 1 container?
There is 90 capsules enough to last 30 days at the recommended dosage.
I dont take orals can I still use Cycle Guard?
Absolutely Cycle Guard has many benefits and has been widely studied for many different diseases.